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首页> 外文OA文献 >SHORT-TERM SYNAPTIC PLASTICITY IN MIGRAINE MOTOR CORTEX: EVIDENCE BY PRECONDITIONING OF HIGH-FREQUENCY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (rTMS) WITH TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS).
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SHORT-TERM SYNAPTIC PLASTICITY IN MIGRAINE MOTOR CORTEX: EVIDENCE BY PRECONDITIONING OF HIGH-FREQUENCY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (rTMS) WITH TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS).

机译：小鼠运动皮层的短期突触可塑性：通过经颅直接电流刺激（tDCS）预处理高频重复性经颅磁刺激（rTMS）的证据。

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Background: Brief 5Hz repetitive transcranial magnetic\udstimulation (rTMS) trains at 120% of the resting- motorthreshold\ud(RMT) intensity determine in healthy subjects a\udpotentiation of motor evoked potentials (MEPs), likely due\udto short-term presynaptic plasticity facilitation. We recently\udshowed paradoxical intensity-dependent MEP changes to\ud5Hz rTMS in migraine with MEP facilitation at 110% and\udinhibition at 130% RMT. This provides evidence of both\udhyper-responsivity and self-limiting hyperexcitability\udcapacity in migraine, likely due to earlier activation of\udinhibitory homeostatic plasticity mechanisms. To explore\udthis, we applied in migraineurs cathodal transcranial Direct\udCurrent Stimulation (tDCS) to reduce motor-cortical\udexcitability and subsequently reassess motor-cortical\udresponse to 5Hz rTMS trains at 130% RMT- intensity.\udMethods: 10 migraine with aura patients received 5Hz\udrTMS of motor cortex at 130% RMT intensity (10 pulses),\udrecording MEP from contralateral abductor pollicis brevis\ud(APB). This protocol was preconditioned by cathodal tDCS\ud(10 min, 1mA intensity). Sham cathodal tDCS was used as\udcontrol.\udResults: As expected MEP amplitude decreased significantly\udduring trains of 5Hz before tDCS preconditioning or\udwith sham tDCS. Conversely, after inhibitory preconditioning\udwith cathodal tDCS, 5Hz rTMS trains determined a\udreduction in the first MEP size and a trend toward MEP\udfacilation during the trains.\udConclusions: Inhibitory cathodal tDCS preconditioning is\udable to normalize the response of migraine motor-cortex to\udrTMS trains at 130% of RMT. This supports the hypothesis\udthat in migraine motor cortex the mechanisms of short-term\udpresynaptic plasticity evaluated by 5Hz rTMS trains could\udbe affected intericatally by an abnormal increased cortical\udexcitability level.
机译：背景：简短的5Hz重复经颅磁刺激（rTMS）训练在静息状态下的运动阈值/ ud（RMT）强度的120％确定健康受试者的运动诱发电位（MEP）增强/可能是由于短期突触前可塑性促进。我们最近\发现偏头痛中偏执强度依赖的MEP改变为\ ud5Hz rTMS，其中MEP促进率为110％，RMT抑制为130％。这提供了偏头痛的\超反应性和自我限制的过度兴奋\能力的证据，这很可能是由于\抑制抑制稳态的可塑性机制的早期激活所致。为了探讨这一点，我们在偏头痛的经颅经颅直流电刺激中应用了tDCS，以降低运动皮层的\反兴奋性，随后以130％RMT强度重新评估运动皮层对5Hz rTMS训练的响应。\ ud方法：10次偏头痛光环患者以130％RMT强度（10个脉冲）接受了5Hz \ udrTMS的运动皮层运动，\\\\\\\\\\\\\\\\\\\\\\，\\\，\“ \，\”，\“ \”，\“ \\\\\\\\\\\\\\\\\\\\\\\\\\\\\，\\\\\，\” \\\\\\\，\“ \\\”，\“ \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\”该方案通过阴极tDCS \ ud（10分钟，强度为1mA）进行预处理。结果：由于预期的MEP振幅在tDCS预处理之前或在使用thamS之前，在5Hz的训练期间，预期的MEP振幅显着降低。相反，在抑制性预处理\用阴极tDCS进行预处理后，5Hz rTMS列车确定了第一个MEP尺寸的减小\在火车期间趋向于MEP \\ ufacilation。\ ud结论：抑制性阴极tDCS预处理\可以使偏头痛运动的反应正常化-皮质到\ udrTMS的训练速度为RMT的130％。这支持以下假设：在偏头痛运动皮层中，由5Hz rTMS训练评估的短期\突触前突触可塑性的机制可能\\受到异常增加的皮层\\可软性水平的影响。

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